PrP Polymorphisms Tightly Control Sheep Prion Replication in Cultured Cells

Prion diseases are fatal neurodegenerative disorders of animals and humans that are characterized by the conversion of the host-encoded prion protein (PrP) to an abnormal isoform. In several species, including humans, polymorphisms in the gene encoding the PrP protein tightly control susceptibility...

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Bibliographic Details
Main Authors: Sabuncu, Elifsu, Petit, Stéphanie, Le Dur, Annick, Lan Lai, Thanh, Vilotte, Jean-Luc, Laude, Hubert, Vilette, Didier
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC141085/
https://ncbi.nlm.nih.gov/pubmed/12552009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.4.2696-2700.2003
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