Relapse of Acute Promyelocytic Leukemia with PML-RARα Mutant Subclones Independent of Proximate All-Trans Retinoic Acid Selection Pressure

Relapse of acute promyelocytic leukemia (APL) following all-trans retinoic acid (ATRA) therapy has been associated with the acquisition of mutations in the high-affinity ATRA binding site in PML-RARα but little information is available about the selection dynamics of the mutation-harboring subclones...

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Detalhes bibliográficos
Main Authors: Gallagher, Robert E., Schachter-Tokarz, Esther L., Zhou, Da-Cheng, Ding, Wei, Kim, Soon H., Sankoorikal, Binu-John, Bi, Wanli, Livak, Kenneth J., Slack, James L., Willman, Cheryl L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1410817/
https://ncbi.nlm.nih.gov/pubmed/16437139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.leu.2404118
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