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Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na–Cl cotransporter is inhibited by wild-type but not mutant WNK4

Mutations in the serine-threonine kinases WNK1 and WNK4 [with no lysine (K) at a key catalytic residue] cause pseudohypoaldosteronism type II (PHAII), a Mendelian disease featuring hypertension, hyperkalemia, hyperchloremia, and metabolic acidosis. Both kinases are expressed in the distal nephron, a...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wilson, Frederick H., Kahle, Kristopher T., Sabath, Ernesto, Lalioti, Maria D., Rapson, Alicia K., Hoover, Robert S., Hebert, Steven C., Gamba, Gerardo, Lifton, Richard P.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC141056/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12515852/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.242735399
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