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Evidence that exposure of the telomere 3′ overhang sequence induces senescence
Normal human cells cease proliferation after a finite number of population doublings, a phenomenon termed replicative senescence. This process, first convincingly described by Hayflick and Moorhead [Hayflick, L. & Moorhead, P. S. (1961) Exp. Cell Res. 25, 595–621] for cultured human fibroblasts...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
The National Academy of Sciences
2003
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC141029/ https://ncbi.nlm.nih.gov/pubmed/12515865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0235444100 |
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