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Identification of a PU.1–IRF4 protein interaction surface predicted by chemical exchange line broadening
Relaxation values reflecting residue-specific line broadening revealed amino acids in the DNA-binding domain of PU.1 on a surface potentially involved in protein–protein interactions. Mutation of these amino acids did not cause protein unfolding but destabilized PU.1–DNA binding. Addition of IFN res...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The National Academy of Sciences
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC141026/ https://ncbi.nlm.nih.gov/pubmed/12518046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0136910100 |
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