Transforming Growth Factor-β Promotes Pro-fibrotic Behavior by Serosal Fibroblasts via PKC and ERK1/2 Mitogen Activated Protein Kinase Cell Signaling

OBJECTIVE: To assess the role of fibroblasts, transforming growth factor (TGF)-β, and cell signal pathways in promoting fibrosis in Crohn's disease (CD). SUMMARY BACKGROUND DATA: Intestinal strictures are a major source of morbidity in CD. Fibroblasts found at sites of stricture promote fibroge...

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Hlavní autoři: Mulsow, Jurgen J. W., Watson, R William G., Fitzpatrick, John M., O'Connell, P Ronan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409881/
https://ncbi.nlm.nih.gov/pubmed/16327498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.sla.0000189606.58343.cd
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