Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response

SIMPLE SUMMARY: To reduce long-term fibrosis risk after radiotherapy, we demonstrated with different experimental approaches that modulation of the epigenetic pattern at the DGKA enhancer can attenuate pro-fibrotic reactions in human fibroblasts. We used (epi)genomic editing of the DGKA enhancer and...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Liu, Chun-Shan, Toth, Reka, Bakr, Ali, Goyal, Ashish, Islam, Md Saiful, Breuer, Kersten, Mayakonda, Anand, Lin, Yu-Yu, Stepper, Peter, Jurkowski, Tomasz P., Veldwijk, Marlon R., Sperk, Elena, Herskind, Carsten, Lutsik, Pavlo, Weichenhan, Dieter, Plass, Christoph, Schmezer, Peter, Popanda, Odilia
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158145/
https://ncbi.nlm.nih.gov/pubmed/34070078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13102455
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