Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability

Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromoso...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Jäkel, Cornelia, Bergmann, Frank, Toth, Reka, Assenov, Yassen, van der Duin, Daniel, Strobel, Oliver, Hank, Thomas, Klöppel, Günter, Dorrell, Craig, Grompe, Markus, Moss, Joshua, Dor, Yuval, Schirmacher, Peter, Plass, Christoph, Popanda, Odilia, Schmezer, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673892/
https://ncbi.nlm.nih.gov/pubmed/29109526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01118-x
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