PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection

The virulence factor IpgD, delivered into nonphagocytic cells by the type III secretion system of the pathogen Shigella flexneri, is a phosphoinositide 4-phosphatase generating phosphatidylinositol 5 monophosphate (PtdIns(5)P). We show that PtdIns(5)P is rapidly produced and concentrated at the entr...

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Autors principals: Pendaries, Caroline, Tronchère, Hélène, Arbibe, Laurence, Mounier, Joelle, Gozani, Or, Cantley, Lewis, Fry, Michael J, Gaits-Iacovoni, Frédérique, Sansonetti, Philippe J, Payrastre, Bernard
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1409730/
https://ncbi.nlm.nih.gov/pubmed/16482216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601001
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