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Ubiquitylation of leptin receptor OB-Ra regulates its clathrin-mediated endocytosis
Leptin receptors are constitutively endocytosed in a ligand-independent manner. To study their endocytosis, leptin receptors OB-Ra and OB-Rb were expressed in HeLa cells. Both receptor isoforms were ubiquitylated, internalized by clathrin-mediated endocytosis and transported to Hrs-positive endosome...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2006
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1409713/ https://ncbi.nlm.nih.gov/pubmed/16482222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600989 |
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