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Depletion of Wee-1 Kinase Is Necessary for both Human Immunodeficiency Virus Type 1 Vpr- and Gamma Irradiation-Induced Apoptosis
Human immunodeficiency virus (HIV) protein R (Vpr) induces G(2) arrest, and prolonged G(2) arrest leads to apoptosis. We find that in HeLa cells the cell cycle regulatory kinase, Wee-1, is depleted following prolonged G(2) arrest induced by Vpr. Of note, small interfering RNAs directed to Wee-1 trig...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140938/ https://ncbi.nlm.nih.gov/pubmed/12525641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.3.2063-2070.2003 |
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