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Increased Levels of Wee-1 Kinase in G(2) Are Necessary for Vpr- and Gamma Irradiation-Induced G(2) Arrest

Human immunodeficiency virus type 1 (HIV-1) Vpr induces cell cycle arrest at the G(2)/M transition and subsequently apoptosis. Here we examined the potential involvement of Wee-1 in Vpr-induced G(2) arrest. Wee-1 is a cellular protein kinase that inhibits Cdc2 activity, thereby preventing cells from...

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書誌詳細
主要な著者: Yuan, Huidong, Kamata, Masakazu, Xie, Yi-Ming, Chen, Irvin S. Y.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2004
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC446131/
https://ncbi.nlm.nih.gov/pubmed/15254189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.15.8183-8190.2004
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