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Increased Levels of Wee-1 Kinase in G(2) Are Necessary for Vpr- and Gamma Irradiation-Induced G(2) Arrest
Human immunodeficiency virus type 1 (HIV-1) Vpr induces cell cycle arrest at the G(2)/M transition and subsequently apoptosis. Here we examined the potential involvement of Wee-1 in Vpr-induced G(2) arrest. Wee-1 is a cellular protein kinase that inhibits Cdc2 activity, thereby preventing cells from...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC446131/ https://ncbi.nlm.nih.gov/pubmed/15254189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.15.8183-8190.2004 |
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