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Depletion of Wee-1 Kinase Is Necessary for both Human Immunodeficiency Virus Type 1 Vpr- and Gamma Irradiation-Induced Apoptosis

Human immunodeficiency virus (HIV) protein R (Vpr) induces G(2) arrest, and prolonged G(2) arrest leads to apoptosis. We find that in HeLa cells the cell cycle regulatory kinase, Wee-1, is depleted following prolonged G(2) arrest induced by Vpr. Of note, small interfering RNAs directed to Wee-1 trig...

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Detalhes bibliográficos
Main Authors: Yuan, Huidong, Xie, Yi-Ming, Chen, Irvin S. Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140938/
https://ncbi.nlm.nih.gov/pubmed/12525641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.3.2063-2070.2003
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