High-Frequency Phenotypic Reversion and Pathogenicity of an Acyclovir-Resistant Herpes Simplex Virus Mutant

A double-guanine-insertion mutation within a run of guanines in the herpes simplex virus gene encoding thymidine kinase (TK) was previously found in an acyclovir-resistant clinical isolate. This mutation was engineered into strain KOS, and stocks were generated from single plaques. Plaque autoradiog...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Griffiths, Anthony, Coen, Donald M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Vaccines and Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140925/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12525666/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.3.2282-2286.2003
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