An Attenuating Mutation in nsP1 of the Sindbis-Group Virus S.A.AR86 Accelerates Nonstructural Protein Processing and Up-Regulates Viral 26S RNA Synthesis

The Sindbis-group alphavirus S.A.AR86 encodes a threonine at nonstructural protein 1 (nsP1) 538 that is associated with neurovirulence in adult mice. Mutation of the nsP1 538 Thr to the consensus Ile found in nonneurovirulent Sindbis-group alphaviruses attenuates S.A.AR86 for adult mouse neurovirule...

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Publicado en:	J Virol
Autores principales:	Heise, Mark T., White, Laura J., Simpson, Dennis A., Leonard, Christopher, Bernard, Kristen A., Meeker, Rick B., Johnston, Robert E.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2003
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140780/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12502831/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.2.1149-1156.2003
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