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A Single Amino Acid Change in the Nuclear Localization Sequence of the nsP2 Protein Affects the Neurovirulence of Semliki Forest Virus
The replicase protein nsP2 of Semliki Forest virus (SFV) has a (648)RRR nuclear localization signal and is transported to the nucleus. SFV-RDR has a single amino acid change which disrupts this sequence and nsP2 nuclear transport. In BHK cells, SFV4 and SFV-RDR replicate to high titers, but SFV-RDR...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2002
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC135702/ https://ncbi.nlm.nih.gov/pubmed/11739703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.1.392-396.2002 |
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