A Single Amino Acid Change in the Nuclear Localization Sequence of the nsP2 Protein Affects the Neurovirulence of Semliki Forest Virus
The replicase protein nsP2 of Semliki Forest virus (SFV) has a (648)RRR nuclear localization signal and is transported to the nucleus. SFV-RDR has a single amino acid change which disrupts this sequence and nsP2 nuclear transport. In BHK cells, SFV4 and SFV-RDR replicate to high titers, but SFV-RDR...
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| Publié dans: | J Virol |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC135702/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11739703/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.1.392-396.2002 |
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