An Attenuating Mutation in nsP1 of the Sindbis-Group Virus S.A.AR86 Accelerates Nonstructural Protein Processing and Up-Regulates Viral 26S RNA Synthesis

The Sindbis-group alphavirus S.A.AR86 encodes a threonine at nonstructural protein 1 (nsP1) 538 that is associated with neurovirulence in adult mice. Mutation of the nsP1 538 Thr to the consensus Ile found in nonneurovirulent Sindbis-group alphaviruses attenuates S.A.AR86 for adult mouse neurovirule...

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Detalhes bibliográficos
Main Authors: Heise, Mark T., White, Laura J., Simpson, Dennis A., Leonard, Christopher, Bernard, Kristen A., Meeker, Rick B., Johnston, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140780/
https://ncbi.nlm.nih.gov/pubmed/12502831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.2.1149-1156.2003
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