Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1

In yeasts, the replication protein Cdc6/Cdc18 is required for the initiation of DNA replication and also for coupling S phase with the following mitosis. In metazoans a role for Cdc6 has only been shown in S phase entry. Here we provide evidence that human Cdc6 (HuCdc6) also regulates the onset of m...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Clay-Farrace, Lorena, Pelizon, Cristina, Santamaria, David, Pines, Jonathon, Laskey, Ronald A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2003
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140731/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12554670/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg046
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