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A conserved tyrosine in the neck of a fungal kinesin regulates the catalytic motor core

The neck domain of fungal conventional kinesins displays characteristic properties which are reflected in a specific sequence pattern. The exchange of the strictly conserved Tyr 362, not present in animals, into Lys, Cys or Phe leads to a failure to dimerize. The destabilizing effect is confirmed by...

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Udgivet i:EMBO J
Principais autores: Schäfer, Friederike, Deluca, Dominga, Majdic, Ulrike, Kirchner, Joachim, Schliwa, Manfred, Moroder, Luis, Woehlke, Günther
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2003
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC140721/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12554646/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg036
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