Heregulin Induces Transcriptional Activation of the Progesterone Receptor by a Mechanism That Requires Functional ErbB-2 and Mitogen-Activated Protein Kinase Activation in Breast Cancer Cells

The present study addresses the capacity of heregulin (HRG), a ligand of type I receptor tyrosine kinases, to transactivate the progesterone receptor (PR). For this purpose, we studied, on the one hand, an experimental model of hormonal carcinogenesis in which the synthetic progestin medroxyprogeste...

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Detalhes bibliográficos
Main Authors: Labriola, Leticia, Salatino, Mariana, Proietti, Cecilia J., Pecci, Adalí, Coso, Omar A., Kornblihtt, Alberto R., Charreau, Eduardo H., Elizalde, Patricia V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140689/
https://ncbi.nlm.nih.gov/pubmed/12529413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.3.1095-1111.2003
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