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Critical Role of Histone Methylation in Tumor Suppressor Gene Silencing in Colorectal Cancer
The mechanism of DNA hypermethylation-associated tumor suppressor gene silencing in cancer remains incompletely understood. Here, we show by chromatin immunoprecipitation that for three genes (P16, MLH1, and the O(6)-methylguanine-DNA methyltransferase gene, MGMT), histone H3 Lys-9 methylation direc...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140684/ https://ncbi.nlm.nih.gov/pubmed/12482974 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.1.206-215.2003 |
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