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15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation

Methylation of promoter DNA contributes to transcriptional silencing of various tumor-suppressor genes in cancer. Transcriptional silencing of 15-lipoxygenase-1 (15-LOX-1) promotes tumorigenesis. Methylation of 15-LOX-1 promoter DNA occurs in some cancers, but its mechanistic role in 15-LOX-1 transc...

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Hlavní autoři: Zuo, Xiangsheng, Shen, Lanlan, Issa, Jean-Pierre, Moy, Ofir, Morris, Jeffrey S., Lippman, Scott M., Shureiqi, Imad
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2410033/
https://ncbi.nlm.nih.gov/pubmed/18198215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-098301
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