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15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation
Methylation of promoter DNA contributes to transcriptional silencing of various tumor-suppressor genes in cancer. Transcriptional silencing of 15-lipoxygenase-1 (15-LOX-1) promotes tumorigenesis. Methylation of 15-LOX-1 promoter DNA occurs in some cancers, but its mechanistic role in 15-LOX-1 transc...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2410033/ https://ncbi.nlm.nih.gov/pubmed/18198215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.07-098301 |
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