Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1

The polycomb protein Bmi-1 represses the INK4a locus, which encodes the tumor suppressors p16 and p14(ARF). Here we report that Bmi-1 is downregulated when WI-38 human fibroblasts undergo replicative senescence, but not quiescence, and extends replicative life span when overexpressed. Life span exte...

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Main Authors: Itahana, Koji, Zou, Ying, Itahana, Yoko, Martinez, Jose-Luis, Beausejour, Christian, Jacobs, Jacqueline J. L., van Lohuizen, Maarten, Band, Vimla, Campisi, Judith, Dimri, Goberdhan P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC140680/
https://ncbi.nlm.nih.gov/pubmed/12482990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.1.389-401.2003
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