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The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors

Polycomb group (PcG) proteins are overexpressed in several human malignancies including breast cancer. In particular, aberrant expression of BMI1 and eZH2 has been linked to metastasis and poor prognosis in cancer patients. At present, very little is known about the pharmacological inhibitors of PcG...

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Hlavní autoři: Bommi, Prashant V, Dimri, Manjari, Sahasrabuddhe, Anagh A, Khandekar, Janardan D, Dimri, Goberdhan P
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3010287/
https://ncbi.nlm.nih.gov/pubmed/20543557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.13.12147
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