Disulfide-Linked Integrase Oligomers Involving C280 Residues Are Formed In Vitro and In Vivo but Are Not Essential for Human Immunodeficiency Virus Replication

The human immunodeficiency virus type 1 integrase (IN) forms an oligomer that integrates both ends of the viral DNA. The nature of the active oligomer is unclear. Recombinant IN obtained under reducing conditions is always in the form of noncovalent oligomers. However, disulfide-linked oligomers of...

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Hlavní autoři: Bischerour, Julien, Leh, Hervé, Deprez, Eric, Brochon, Jean-Claude, Mouscadet, Jean-François
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2003
Témata:
Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC140589/
https://ncbi.nlm.nih.gov/pubmed/12477818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.1.135-141.2003
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