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Preferential hydrolysis of gap and bulge sites in DNA by Ce(IV)/EDTA complex

A new strategy for site-selective DNA hydrolysis, which takes advantage of the difference in reactivity between the phosphodiester linkages at the target site and the others, is presented. As the molecular scissors, homogeneous Ce(IV)/ethylenediamine-N,N,N′,N′-tetraacetate (EDTA) complex is used wit...

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Detalhes bibliográficos
Main Authors: Kitamura, Yoshihito, Komiyama, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140562/
https://ncbi.nlm.nih.gov/pubmed/12364619
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