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Deregulation of the Egfr/Ras Signaling Pathway Induces Age-related Brain Degeneration in the Drosophila Mutant vap

Ras signaling has been shown to play an important role in promoting cell survival in many different tissues. Here we show that upregulation of Ras activity in adult Drosophila neurons induces neuronal cell death, as evident from the phenotype of vacuolar peduncle (vap) mutants defective in the Droso...

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Hlavní autoři: Botella, José A., Kretzschmar, Doris, Kiermayer, Claudia, Feldmann, Pascale, Hughes, David A., Schneuwly, Stephan
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2003
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC140241/
https://ncbi.nlm.nih.gov/pubmed/12529440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E02-05-0297
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