Phase I study of intermittent and chronomodulated oral therapy with capecitabine in patients with advanced and/or metastatic cancer

BACKGROUND: The combination of capecitabine and gemcitabine at Fixed Dose Rate (FDR) has been demonstrated to be well tolerated, with apparent efficacy in patients with advanced cancers. FDR gemcitabine infusion leads to enhanced intracellular accumulation of drug and possible augmented clinical eff...

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Detalhes bibliográficos
Main Authors: Santini, Daniele, Vincenzi, Bruno, Schiavon, Gaia, La Cesa, Annalisa, Gasparro, Simona, Vincenzi, Angelo, Tonini, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1402306/
https://ncbi.nlm.nih.gov/pubmed/16504126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-42
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