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Analysis of the mechanism of action of non-deletion hereditary persistence of fetal hemoglobin mutants in transgenic mice
Transgenic mice carrying an (A)γ gene construct containing a –382 5′ truncation of the (A)γ gene promoter have a phenotype of hereditary persistence of fetal hemoglobin (HPFH) but, when the CACCC box of the –382(A)γ promoter is deleted, there is no γ gene expression in the adult mice. We used this s...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2001
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140187/ https://ncbi.nlm.nih.gov/pubmed/11226166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.1.157 |
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