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Analysis of the mechanism of action of non-deletion hereditary persistence of fetal hemoglobin mutants in transgenic mice

Transgenic mice carrying an (A)γ gene construct containing a –382 5′ truncation of the (A)γ gene promoter have a phenotype of hereditary persistence of fetal hemoglobin (HPFH) but, when the CACCC box of the –382(A)γ promoter is deleted, there is no γ gene expression in the adult mice. We used this s...

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Sonraí Bibleagrafaíochta
Main Authors: Li, Qiliang, Duan, Zhi-Jun, Stamatoyannopoulos, George
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2001
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC140187/
https://ncbi.nlm.nih.gov/pubmed/11226166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.1.157
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