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Dose independent pharmacokinetics of mexiletine in healthy volunteers.

In 12 healthy volunteers who received orally 100, 200, 300, 400 and 600 mg mexiletine at weekly intervals, the maximum plasma concentration of mexiletine and AUC increased linearly with the dose of mexiletine. Between doses there were no significant differences in the values for clearance and volume...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pringle, T, Fox, J, McNeill, J A, Kinney, C D, Liddle, J, Harron, D W, Shanks, R G
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1986
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1400855/
https://ncbi.nlm.nih.gov/pubmed/3964531
Tagiau: Ychwanegu Tag
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