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Dose independent pharmacokinetics of mexiletine in healthy volunteers.

In 12 healthy volunteers who received orally 100, 200, 300, 400 and 600 mg mexiletine at weekly intervals, the maximum plasma concentration of mexiletine and AUC increased linearly with the dose of mexiletine. Between doses there were no significant differences in the values for clearance and volume...

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Bibliografske podrobnosti
Main Authors: Pringle, T, Fox, J, McNeill, J A, Kinney, C D, Liddle, J, Harron, D W, Shanks, R G
Format: Artigo
Jezik:Inglês
Izdano: 1986
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1400855/
https://ncbi.nlm.nih.gov/pubmed/3964531
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