Pharmacokinetics of High-Dose Oseltamivir in Healthy Volunteers

The effects of loading doses and probenecid coadministration on oseltamivir pharmacokinetics at four increasing dose levels in groups of eight healthy adult Thai volunteers (125 individual series) were evaluated. Doses of up to 675 mg were well-tolerated. The pharmacokinetics were dose linear. Oselt...

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Main Authors: Wattanagoon, Y., Stepniewska, K., Lindegårdh, N., Pukrittayakamee, S., Silachamroon, U., Piyaphanee, W., Singtoroj, T., Hanpithakpong, W., Davies, G., Tarning, J., Pongtavornpinyo, W., Fukuda, C., Singhasivanon, P., Day, N. P. J., White, N. J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650521/
https://ncbi.nlm.nih.gov/pubmed/19104028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00588-08
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