Pharmacokinetics of High-Dose Oseltamivir in Healthy Volunteers

The effects of loading doses and probenecid coadministration on oseltamivir pharmacokinetics at four increasing dose levels in groups of eight healthy adult Thai volunteers (125 individual series) were evaluated. Doses of up to 675 mg were well-tolerated. The pharmacokinetics were dose linear. Oselt...

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Autori principali: Wattanagoon, Y., Stepniewska, K., Lindegårdh, N., Pukrittayakamee, S., Silachamroon, U., Piyaphanee, W., Singtoroj, T., Hanpithakpong, W., Davies, G., Tarning, J., Pongtavornpinyo, W., Fukuda, C., Singhasivanon, P., Day, N. P. J., White, N. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650521/
https://ncbi.nlm.nih.gov/pubmed/19104028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00588-08
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