Phosphorylation of Eukaryotic Initiation Factor 2 by Heme-Regulated Inhibitor Kinase-Related Protein Kinases in Schizosaccharomyces pombe Is Important for Resistance to Environmental Stresses

Protein synthesis is regulated by the phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) in response to different environmental stresses. One member of the eIF2α kinase family, heme-regulated inhibitor kinase (HRI), is activated under heme-deficient conditions and blocks prot...

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Bibliographic Details
Main Authors: Zhan, Ke, Vattem, Krishna M., Bauer, Bettina N., Dever, Thomas E., Chen, Jane-Jane, Wek, Ronald C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC139816/
https://ncbi.nlm.nih.gov/pubmed/12242291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.20.7134-7146.2002
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