Macrophage metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in mice

BACKGROUND: Pulmonary fibrosis is characterized by excessive deposition of extracellular matrix in the interstitium resulting in respiratory failure. The role of remodeling mediators such as metalloproteinases (MMPs) and their inhibitors (TIMPs) in the fibrogenic process remains misunderstood. In pa...

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Autori principali: Manoury, Boris, Nenan, Soazig, Guenon, Isabelle, Boichot, Elisabeth, Planquois, Jean-Michel, Bertrand, Claude P, Lagente, Vincent
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2006
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1397817/
https://ncbi.nlm.nih.gov/pubmed/16504062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-3-2
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