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Lsm Proteins Are Required for Normal Processing of Pre-tRNAs and Their Efficient Association with La-Homologous Protein Lhp1p
Depletion of any of the five essential proteins Lsm2p to Lsm5p and Lsm8p leads to strong accumulation of all tested unspliced pre-tRNA species, as well as accumulation of 5′ and 3′ unprocessed species. Aberrant 3′-extended pre-tRNAs were detected, presumably due to stabilization of transcripts that...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139769/ https://ncbi.nlm.nih.gov/pubmed/12077351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.14.5248-5256.2002 |
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