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Lsm Proteins Are Required for Normal Processing of Pre-tRNAs and Their Efficient Association with La-Homologous Protein Lhp1p

Depletion of any of the five essential proteins Lsm2p to Lsm5p and Lsm8p leads to strong accumulation of all tested unspliced pre-tRNA species, as well as accumulation of 5′ and 3′ unprocessed species. Aberrant 3′-extended pre-tRNAs were detected, presumably due to stabilization of transcripts that...

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Udgivet i:Mol Cell Biol
Principais autores: Kufel, Joanna, Allmang, Christine, Verdone, Loredana, Beggs, Jean D., Tollervey, David
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2002
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139769/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12077351/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.14.5248-5256.2002
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