Lsm Proteins Are Required for Normal Processing of Pre-tRNAs and Their Efficient Association with La-Homologous Protein Lhp1p

Depletion of any of the five essential proteins Lsm2p to Lsm5p and Lsm8p leads to strong accumulation of all tested unspliced pre-tRNA species, as well as accumulation of 5′ and 3′ unprocessed species. Aberrant 3′-extended pre-tRNAs were detected, presumably due to stabilization of transcripts that...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Kufel, Joanna, Allmang, Christine, Verdone, Loredana, Beggs, Jean D., Tollervey, David
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2002
Soggetti:	Gene Expression
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139769/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12077351/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.14.5248-5256.2002
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