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The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a

Dnmt3L is required for the establishment of maternal methylation imprints at imprinting centers (ICs). Dnmt3L, however, lacks the conserved catalytic domain common to DNA methyltransferases. In an attempt to define its function, we coexpressed DNMT3L with each of the two known de novo methyltransfer...

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Autori principali: Chédin, Frédéric, Lieber, Michael R., Hsieh, Chih-Lin
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC139244/
https://ncbi.nlm.nih.gov/pubmed/12481029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262443999
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