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Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts

Members of the mammalian p160 family, such as GRIP1, are known as glucocorticoid receptor (GR) coactivators; at certain glucocorticoid response elements (GREs), however, GRIP1 acts as a GR corepressor. We characterized functional interactions of GR and GRIP1 in a repression complex where GR tethers...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Rogatsky, Inez, Luecke, Hans F., Leitman, Dale C., Yamamoto, Keith R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139207/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12481024/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.262671599
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