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Site-directed recombination via bifunctional PNA–DNA conjugates

Site-specific DNA binding molecules offer the potential for genetic manipulation of mammalian cells. Peptide nucleic acids (PNAs) are a DNA mimic in which the purine and pyrimidine bases are attached to a polyamide backbone. PNAs bind with high affinity to single-stranded DNA via Watson–Crick base p...

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Detalhes bibliográficos
Main Authors: Rogers, Faye A., Vasquez, Karen M., Egholm, Michael, Glazer, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC139206/
https://ncbi.nlm.nih.gov/pubmed/12461167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262556899
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