The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5′ splice sites

The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5′ splice site (ss) at early stages of spliceosome assembly. Recruitment of U1 to a class of weak 5′ ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5′ ss. Here we describ...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Förch, Patrik, Puig, Oscar, Martínez, Concepción, Séraphin, Bertrand, Valcárcel, Juan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2002
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139089/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12486009/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf668
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