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The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5′ splice sites
The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5′ splice site (ss) at early stages of spliceosome assembly. Recruitment of U1 to a class of weak 5′ ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5′ ss. Here we describ...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139089/ https://ncbi.nlm.nih.gov/pubmed/12486009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf668 |
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