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Antigenomic delta ribozyme variants with mutations in the catalytic core obtained by the in vitro selection method

We have used the in vitro selection method to search for catalytically active variants of the antigenomic delta ribozyme with mutations in the regions that constitute the ribozyme active site: L3, J1/4 and J4/2. In the initial combinatorial library 16 nt positions were randomized and the library con...

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Detalhes bibliográficos
Main Authors: Łęgiewicz, Michał, Wichłacz, Agnieszka, Brzezicha, Bartosz, Ciesiołka, Jerzy
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1388270/
https://ncbi.nlm.nih.gov/pubmed/16513845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl018
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