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Tyrosine kinase signalling in breast cancer: Insulin-like growth factors and their receptors in breast cancer

The insulin-like growth factor (IGF) system exerts pleiotropic effects on mammalian cells. This review focuses on type I IGF receptor (IGF1R)-mediated signal transduction and its relevance in breast cancer. Upon activation by the IGFs, IGF1R, a transmembrane tyrosine kinase receptor, undergoes autop...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Zhang, Xihong, Yee, Douglas
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC138771/
https://ncbi.nlm.nih.gov/pubmed/11250706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr50
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