Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor β2 expression via cGMP

Nitric oxide plays an important role in immune regulation. We have shown that although high concentrations of NO generally were immune-suppressive, low concentrations of NO selectively enhanced the differentiation of T helper (Th)1 cells but not Th2 cells. This finding provided an explanation for th...

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Bibliographic Details
Main Authors: Niedbala, Wanda, Wei, Xiao-qing, Campbell, Carol, Thomson, Duncan, Komai-Koma, Mousa, Liew, Foo Y.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC138586/
https://ncbi.nlm.nih.gov/pubmed/12451176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252464599
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