Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo

Knockout of the murine retinoic acid (RA)-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2) gene leads to early morphogenetic defects and embryonic lethality. Using a RA-responsive reporter transgene, we have looked for RA-generating activities in Raldh2-null mouse embryos and investigated...

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Main Authors: Niederreither, Karen, Vermot, Julien, Fraulob, Valérie, Chambon, Pierre, Dollé, Pascal
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2002
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC138573/
https://ncbi.nlm.nih.gov/pubmed/12454286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.252626599
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