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Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment

Retinoic acid (RA), an active vitamin A metabolite, is a key signaling molecule in vertebrate embryos. Morphogenetic RA gradients are thought to be set up by tissue-specific actions of retinaldehyde dehydrogenases (RALDHs) and catabolizing enzymes. According to the species, two enzymatic pathways (β...

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Detalhes bibliográficos
Main Authors: Rhinn, Muriel, Schuhbaur, Brigitte, Niederreither, Karen, Dollé, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189044/
https://ncbi.nlm.nih.gov/pubmed/21930923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1103877108
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