Tumour necrosis factor production by IL-2-activated macrophages in vitro and in vivo.

Purified human and murine monocytes can be activated in vitro by human recombinant IL-2 to secrete tumour necrosis factor (TNF). TNF mRNA is detected within 4 h of addition of IL-2. Signal transduction does not appear to require expression of the Tac peptide of the IL-2 receptor. IL-2 does, however,...

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Detalhes bibliográficos
Main Authors: Economou, J S, McBride, W H, Essner, R, Rhoades, K, Golub, S, Holmes, E C, Morton, D L
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1385323/
https://ncbi.nlm.nih.gov/pubmed/2788610
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