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Stronger control of ATP/ADP by proton leak in pancreatic β-cells than skeletal muscle mitochondria

Pancreatic beta cells respond to rising blood glucose concentrations by increasing their oxidative metabolism, which leads to an increased ATP/ADP ratio, closure of K(ATP) channels, depolarization of the plasma membrane potential, influx of calcium and the eventual secretion of insulin. Such a signa...

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Detalhes bibliográficos
Main Authors: Affourtit, Charles, Brand, Martin D.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383673/
https://ncbi.nlm.nih.gov/pubmed/16137248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051280
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